Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28176249 | 0.68 | HTR2C (0.52) | RAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL28720635 | 0.68 | ALOX5 (0.58) | LMNAGAA | |
| SCHEMBL417371 | 0.67 | HTT (0.51) | RAB9ADHFREGFRLMNAALDH1A1 | |
| SCHEMBL19974165 | 0.67 | L3MBTL1 (0.46) | RAB9ALMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19974166 | 0.67 | L3MBTL1 (0.46) | RAB9ALMNAALDH1A1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL5008548 | 0.67 | L3MBTL1 (0.54) | RAB9ALMNASMN1; SMN2NPC1 | |
| SCHEMBL6056911 | 0.67 | PDE5A (0.46) | RAB9ALMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7879205 | 0.66 | EPHX2 (0.38) | RAB9AHSD17B10ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL21066336 | 0.65 | L3MBTL1 (0.54) | RAB9ALMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL17925452 | 0.65 | LMNA (0.52) | RAB9ADHFREGFRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |