Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.44 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP3 | Q9H4L4 | 1/20 | 0.44 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.44 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamide SCHEMBL3573443 | 0.92 | PTPN22 (0.55) | PTPN22LDHACTRB1ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL29399146 | 0.90 | PTPN22 (0.60) | PTPN22LDHAALDH1A1CYP3A4HPGD | |
| SCHEMBL144495 | 0.90 | PTPN22 (0.60) | PTPN22LDHAALDH1A1CYP3A4HPGD | |
| SCHEMBL8003535 | 0.90 | PTPN22 (0.60) | PTPN22LDHAALDH1A1CYP3A4HPGD | |
| SCHEMBL30168079 | 0.90 | PTPN22 (0.60) | PTPN22LDHAALDH1A1CYP3A4HPGD | |
| Hydrochloric Acid SCHEMBL588687 | 0.90 | PTPN22 (0.60) | PTPN22LDHAALDH1A1CYP3A4HPGD | |
| Hydrogen Sulfide SCHEMBL28776700 | 0.88 | PTPN22 (0.58) | PTPN22LDHAALDH1A1CYP3A4HPGD | |
| Methane SCHEMBL29209224 | 0.88 | PTPN22 (0.58) | PTPN22LDHAALDH1A1CYP3A4HPGD | |
| Sulfuric Acid SCHEMBL6075070 | 0.82 | ALDH1A1 (0.45) | PTPN22SUMO2SUMO1SENP7SENP3 | |
| SCHEMBL29484713 | 0.80 | HPRT1 (0.59) | PTPN22LDHAALDH1A1CYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095105-A1 | REACTIVE COLORANTS, PRODUCTION AND USE THEREOF | Ciba SC Holding AG (CH) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000004099-A1 | REACTIVE COLORANTS, PRODUCTION AND USE THEREOF | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2000-01-27 | — | — | WO | disclosed |
| EP-0094055-B1 | MONOAZO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS DYESTUFFS | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-12-03 | — | — | EP | disclosed |
| EP-0094055-A1 | Monoazo compounds, process for their preparation and their use as dyestuffs | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-11-16 | — | — | EP | disclosed |