Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886529 | 0.90 | NPC1 (0.37) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL6893394 | 0.88 | CHEK1 (0.37) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL6894370 | 0.86 | ALDH1A1 (0.40) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL7883671 | 0.80 | MAPK14 (0.34) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL6893430 | 0.77 | NPC1 (0.44) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL584020 | 0.77 | CHRNB2 (0.43) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL10234729 | 0.76 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6893777 | 0.76 | CHEK1 (0.44) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL7874782 | 0.75 | PIK3CA (0.38) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL6891750 | 0.75 | EGFR (0.36) | NPC1RAB9AMEN1KMT2ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |