Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 7/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879358 | 1.00 | PIM1 (0.42) | PIM1PIM2PIM3KCNH2HPGD | |
| SCHEMBL7879355 | 1.00 | PIM1 (0.42) | PIM1PIM2PIM3KCNH2HPGD | |
| SCHEMBL7879307 | 0.83 | KDM4E (0.45) | PPARGPPARARAB9AHRH3 | |
| SCHEMBL10366704 | 0.81 | HPGD (0.61) | PIM1PIM2HPGDPPARGPPARA | |
| SCHEMBL10364994 | 0.81 | HPGD (0.61) | PIM1PIM2HPGDPPARGPPARA | |
| SCHEMBL10364971 | 0.81 | HPGD (0.61) | PIM1PIM2HPGDPPARGPPARA | |
| SCHEMBL9520104 | 0.81 | KDM4E (0.45) | PIM1PIM2PIM3KCNH2HPGD | |
| SCHEMBL9520097 | 0.81 | KDM4E (0.45) | PIM1PIM2PIM3KCNH2HPGD | |
| SCHEMBL9316520 | 0.80 | PIM1 (0.45) | PIM1PIM2PIM3KCNH2HPGD | |
| SCHEMBL9370030 | 0.80 | PIM1 (0.45) | PIM1PIM2PIM3KCNH2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329408-B1 | HYPOCHOLESTEROLEMIC AGENTS; OPTICALLY PURE | PFIZER INC. | 2001-12-11 | — | — | US | disclosed |