Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879034 | 0.94 | HTR1A (0.55) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL7877114 | 0.93 | NPC1 (0.49) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL7880351 | 0.93 | HTR1A (0.54) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL7881308 | 0.93 | ADRA2A (0.58) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL6959565 | 0.93 | HTR1A (0.63) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL7881273 | 0.91 | HTR1A (0.53) | HTR1ASLC6A4ACHE | |
| SCHEMBL27417126 | 0.88 | HTR1A (0.55) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL6959865 | 0.88 | BCHE (0.49) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL7352278 | 0.86 | BCHE (0.47) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL7878911 | 0.86 | CCR3 (0.49) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333339-B1 | CENTRAL SYSTEM DISORDERS, SCHIZOPHRENIA AND COGNITION ACTIVATORS | MERCK PATENT GELLSCHAFT MIT BESCHRANKTER (DE) | 2001-12-25 | — | — | US | disclosed |