SCHEMBL7880417

SCHEMBL7880417

COc1ccc(C2c3ccsc3CCN2C(=O)c2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.75

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.63
ABCG2 Q9UNQ0 1/20 0.58
LHCGR P22888 7/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7880530 1.00 POLB (0.63) POLBABCG2LHCGR
SCHEMBL7891790 0.92 POLB (0.69) POLBLHCGR
SCHEMBL7880458 0.90 LHCGR (0.54) POLBABCG2LHCGR
SCHEMBL7889959 0.90 LHCGR (0.55) POLBABCG2LHCGR
SCHEMBL7880305 0.90 LHCGR (0.58) POLBABCG2LHCGR
SCHEMBL7887385 0.90 POLB (0.63) POLBLHCGR
SCHEMBL7880277 0.89 LHCGR (0.58) POLBLHCGR
SCHEMBL7891804 0.89 LHCGR (0.64) POLBLHCGR
SCHEMBL7889850 0.89 POLB (0.54) POLBABCG2LHCGR
SCHEMBL7880450 0.89 LHCGR (0.54) POLBLHCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6177443-B1 ANTIDIABETIC AGENTS NOVO NORDISK A/S (DK) 2001-01-23 US claimed
EP-0973778-A1 4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 2000-01-26 EP claimed
WO-1998040385-A1 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1998-09-17 WO claimed
US-6177443-B1 ANTIDIABETIC AGENTS NOVO NORDISK A/S (DK) 2001-01-23 US disclosed
EP-0973778-A1 4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 2000-01-26 EP disclosed
WO-1998040385-A1 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1998-09-17 WO disclosed