Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219661 | 1.00 | ATM (0.47) | ATMMAOAMAOBCYP2C9GAA | |
| SCHEMBL3374471 | 0.83 | ATM (0.47) | ATMMAOAMAOBCYP2C9GAA | |
| SCHEMBL88261 | 0.81 | MAOA (0.58) | ATMMAOAMAOBCYP2C9HDAC3 | |
| SCHEMBL29413779 | 0.81 | MAOA (0.58) | ATMMAOAMAOBCYP2C9HDAC3 | |
| SCHEMBL13061690 | 0.77 | ALOX15 (0.46) | ANPEPMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4422553 | 0.76 | ATM (0.46) | ATMMAOAMAOBCYP2C9HDAC3 | |
| SCHEMBL4422548 | 0.76 | ATM (0.46) | ATMMAOAMAOBCYP2C9HDAC3 | |
| SCHEMBL20785351 | 0.76 | MAOA (0.46) | ATMMAOAMAOBCYP2C9GAA | |
| SCHEMBL20785354 | 0.76 | MAOA (0.46) | ATMMAOAMAOBCYP2C9GAA | |
| SCHEMBL20785353 | 0.76 | MAOA (0.46) | ATMMAOAMAOBCYP2C9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454229-B1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | RISEN (SHANGHAI) PHARMA TECH CO LTD (CN) | 2017-09-13 | — | — | EP | disclosed |
| US-20160220519-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | LU, Jiasheng (CN) | 2016-08-04 | — | — | US | disclosed |
| US-20160220519-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | LU, Jiasheng (CN) | 2016-08-04 | — | — | US | disclosed |
| US-9233913-B2 | Amino acid derivatives for the treatment of neuropathic pain | Kong, Xianqi (CA) | 2016-01-12 | — | — | US | disclosed |
| US-9233913-B2 | Amino acid derivatives for the treatment of neuropathic pain | Kong, Xianqi (CA) | 2016-01-12 | — | — | US | disclosed |
| US-20140171507-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2014-06-19 | — | — | US | disclosed |
| US-20140171507-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2014-06-19 | — | — | US | disclosed |
| US-20120208876-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2012-08-16 | — | — | US | disclosed |
| US-20120208876-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2012-08-16 | — | — | US | disclosed |
| WO-2010127439-A1 | AMMO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | BELLUS HEALTH (INTERNATIONAL) LIMITED (CH) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171507-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | GAP43, OPRL1, NGF | ATM 2436/4885MAOA 2395/4885MAOB 1954/4885 |
| US-20160220519-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | GAP43, OPRL1, NGF | ATM 2433/4885MAOA 2355/4885MAOB 1908/4885 |
| US-20120208876-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | GAP43, OPRL1, NGF | ATM 2436/4885MAOA 2395/4885MAOB 1954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.