Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.59 |
| ▸ | F3 | P13726 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.56 |
| ▸ | NHERF1 | O14745 | 6/20 | 0.55 |
| ▸ | PYGL | P06737 | 4/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GUSB | P08236 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7879661 | 0.99 | F7 (0.57) | F7F3MEN1KMT2ARXFP1 | |
| SCHEMBL8170113 | 0.84 | F7 (0.57) | F7F3MEN1KMT2ARXFP1 | |
| SCHEMBL4933623 | 0.82 | F7 (0.66) | F7F3MEN1KMT2ARXFP1 | |
| SCHEMBL1952751 | 0.81 | KDM4E (0.67) | NPC1RAB9A | |
| SCHEMBL764543 | 0.80 | F7 (0.72) | F7F3MEN1KMT2ARXFP1 | |
| Hydrochloric Acid SCHEMBL7884810 | 0.79 | KDM4E (0.65) | NPC1RAB9A | |
| SCHEMBL27464367 | 0.79 | F7 (0.66) | F7F3MEN1KMT2ARXFP1 | |
| SCHEMBL12101200 | 0.79 | ALOX15 (0.77) | F7F3MEN1KMT2ARXFP1 | |
| SCHEMBL6162686 | 0.79 | PYGL (0.65) | NHERF1PYGLHRH4HRH3 | |
| SCHEMBL27477428 | 0.79 | F7 (0.57) | F7F3MEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114393-A | ADMINISTERING A BENZOYLGUANIDINE COMPOUND ANTIPROTOZOA AGENT | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-09-05 | — | — | US | claimed |
| EP-0901788-A2 | Use of inhibitors of the sodium hydrogen exchange in the manufacture of a medicament | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-17 | — | — | EP | claimed |
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| US-6114393-A | ADMINISTERING A BENZOYLGUANIDINE COMPOUND ANTIPROTOZOA AGENT | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-09-05 | — | — | US | disclosed |
| EP-0901788-A2 | Use of inhibitors of the sodium hydrogen exchange in the manufacture of a medicament | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-17 | — | — | EP | disclosed |
| EP-0622356-B1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMA (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0622356-A1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-02 | — | — | EP | disclosed |