Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.64 |
| ▸ | PDE4A | P27815 | 2/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10381776 | 0.79 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL6052113 | 0.78 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL10657390 | 0.77 | PDE3B (0.98) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Motapizone SCHEMBL385669 | 0.75 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10374774 | 0.74 | PBRM1 (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Motapizone SCHEMBL10671058 | 0.74 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7395148 | 0.73 | PDE3A (0.63) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10381897 | 0.73 | GPR119 (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10554354 | 0.72 | PDE3A (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL10994723 | 0.71 | PDE3B (0.83) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990001479-A1 | 4,5-DIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR PRODUCING THEM AND THEIR USE | CASSELLA AKTIENGESELLSCHAFT (DE) | 1990-02-22 | — | — | WO | disclosed |