SCHEMBL7883531

SCHEMBL7883531

COc1ccc(N=Nc2ccc(O)cc2O)c([N+](=O)[O-])c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.53
MAPT P10636 6/20 0.53
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
LMNA P02545 2/20 0.53
POLB P06746 1/20 0.53
HTT P42858 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
NPC1 O15118 4/20 0.48
RAB9A P51151 4/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
KDM4E B2RXH2 2/20 0.46
MAPK1 P28482 3/20 0.44
BACE1 P56817 1/20 0.43
EGFR P00533 1/20 0.43
ABCB1 P08183 1/20 0.43
ABCC1 P33527 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.41
RAF1 P04049 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7883529 1.00 ALDH1A1 (0.53) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL9178354 0.86 NPC1 (0.54) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL9178347 0.86 NPC1 (0.54) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL8380230 0.84 MAPT (0.44) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL8380227 0.84 MAPT (0.44) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL23689924 0.84 MEN1 (0.62) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL8081893 0.84 MAPT (0.53) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL8083647 0.82 MEN1 (0.57) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL4137696 0.81 KMT2A (0.40) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL4137698 0.81 KMT2A (0.40) ALDH1A1MAPTMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6203578-B1 ORGANOSILICON CONTAINING ANTHRAQUINONE DYE, MONOAZO DYES, QUINONE DYES L'OREAL (FR) 2001-03-20 US disclosed
US-6176885-B1 MODIFIED POLYSILOXANE OLIGOMER L'OREAL (FR) 2001-01-23 US disclosed
EP-0751134-B1 Method of synthesizing 2-(2'-hydroxyphenyl) benzotriazole compounds EASTMAN KODAK CO (US) 2000-08-30 EP disclosed
EP-0839815-B1 Use of silicon compounds for dyeing human keratinic fibres; compounds and compositions OREAL (FR) 2000-03-01 EP disclosed
US-6027537-A LINEAR OR CYCLIC POLYSILOXANES ENDCAPPED WITH OR CONTAINING AT LEAST ONE CHROMOPHORIC GROUP OF QUINONE OR AZO TYPE AS DIRECT DYES IN DYE COMPOSITIONS FOR DYEING HAIR L'OREAL (FR) 2000-02-22 US disclosed
US-5962484-A SUNSCREEN COSMETICS SOCIETE L'OREAL S.A. (FR) 1999-10-05 US disclosed
EP-0839815-A1 Use of silicon compounds for dyeing human keratinic fibres; compounds and compositions L'OREAL (FR) 1998-05-06 EP disclosed
EP-0708108-B1 Solar filtres, cosmetic sunscreen compositions containing them, and their application OREAL (FR) 1997-11-12 EP disclosed
US-5670654-A CYCLIZATION IN PRESENCE OF REDUCING AGENT EASTMAN KODAK COMPANY (US) 1997-09-23 US disclosed
US-5663270-A Photoprotective/cosmetic compositions comprising substituted polyorganosiloxanes/polyorganosilanes L'OREAL (FR) 1997-09-02 US disclosed
EP-0751134-A1 Method of synthesizing 2-(2'-hydroxyphenyl) benzotriazole compounds EASTMAN KODAK COMPANY (US) 1997-01-02 EP disclosed
EP-0708108-A1 Solar filtres, cosmetic sunscreen compositions containing them, and their application L'OREAL (FR) 1996-04-24 EP disclosed