SCHEMBL4137696

SCHEMBL4137696

COc1ccc(/N=N/c2ccc(OCCC[Si](C)(C)C)cc2O)c([N+](=O)[O-])c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.40
MEN1 O00255 7/20 0.40
RAB9A P51151 5/20 0.40
NPC1 O15118 4/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
MAPT P10636 8/20 0.39
ALDH1A1 P00352 6/20 0.39
KDM4E B2RXH2 2/20 0.39
SMN1; SMN2 Q16637 5/20 0.38
MAPK1 P28482 2/20 0.37
RAF1 P04049 1/20 0.37
LMNA P02545 2/20 0.37
NPSR1 Q6W5P4 2/20 0.37
PKM P14618 1/20 0.37
HPGD P15428 1/20 0.36
AKR1C3 P42330 1/20 0.36
AKR1C2 P52895 1/20 0.36
BACE1 P56817 1/20 0.36
ABCB1 P08183 1/20 0.36
ABCC1 P33527 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4137698 1.00 KMT2A (0.40) KMT2AMEN1RAB9ANPC1L3MBTL1
SCHEMBL7883529 0.81 ALDH1A1 (0.53) KMT2AMEN1RAB9ANPC1L3MBTL1
SCHEMBL7883531 0.81 ALDH1A1 (0.53) KMT2AMEN1RAB9ANPC1L3MBTL1
SCHEMBL8380227 0.81 MAPT (0.44) KMT2AMEN1RAB9ANPC1L3MBTL1
SCHEMBL8380230 0.81 MAPT (0.44) KMT2AMEN1RAB9ANPC1L3MBTL1
SCHEMBL9178347 0.79 NPC1 (0.54) KMT2AMEN1RAB9ANPC1L3MBTL1
SCHEMBL9178354 0.79 NPC1 (0.54) KMT2AMEN1RAB9ANPC1L3MBTL1
SCHEMBL9514033 0.75 CA1 (0.34) KMT2AMEN1RAB9ANPC1L3MBTL1
SCHEMBL15189810 0.72 MEN1 (0.39) KMT2AMEN1RAB9ANPC1L3MBTL1
SCHEMBL9817551 0.71 KMT2A (0.38) KMT2AMEN1RAB9ANPC1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1484051-B1 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. OREAL (FR) 2013-08-21 EP claimed
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF L'OREAL (FR) 2009-03-19 US claimed
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof L'OREAL (FR) 2005-01-13 US claimed
EP-1484051-A2 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. L'OREAL (FR) 2004-12-08 EP claimed
EP-1484051-B1 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. OREAL (FR) 2013-08-21 EP disclosed
EP-1484051-B1 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. OREAL (FR) 2013-08-21 EP disclosed
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF L'OREAL (FR) 2009-03-19 US disclosed
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF L'OREAL (FR) 2009-03-19 US disclosed
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof L'OREAL (FR) 2005-01-13 US disclosed
EP-1484051-A2 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. L'OREAL (FR) 2004-12-08 EP disclosed
US-6203578-B1 ORGANOSILICON CONTAINING ANTHRAQUINONE DYE, MONOAZO DYES, QUINONE DYES L'OREAL (FR) 2001-03-20 US disclosed
US-6176885-B1 MODIFIED POLYSILOXANE OLIGOMER L'OREAL (FR) 2001-01-23 US disclosed
EP-0839815-B1 Use of silicon compounds for dyeing human keratinic fibres; compounds and compositions OREAL (FR) 2000-03-01 EP disclosed
US-6027537-A LINEAR OR CYCLIC POLYSILOXANES ENDCAPPED WITH OR CONTAINING AT LEAST ONE CHROMOPHORIC GROUP OF QUINONE OR AZO TYPE AS DIRECT DYES IN DYE COMPOSITIONS FOR DYEING HAIR L'OREAL (FR) 2000-02-22 US disclosed
EP-0839815-A1 Use of silicon compounds for dyeing human keratinic fibres; compounds and compositions L'OREAL (FR) 1998-05-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof TYR, AAAS, ALAD KMT2A 1215/4885MEN1 3700/4885RAB9A 2539/4885
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF TYR, AAAS, ALAD KMT2A 1027/4885MEN1 3854/4885RAB9A 2499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.