SCHEMBL788418

SCHEMBL788418

N[C@@H](CS)C(=O)OC[C@@H](O)CO

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.41
SLC7A11 Q9UPY5 1/20 0.41
LMNA P02545 3/20 0.41
KDM4E B2RXH2 1/20 0.40
DUSP3 P51452 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
DGKA P23743 1/20 0.34
FAAH O00519 2/20 0.33
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL592069 1.00 PTGS1 (0.41) PTGS1SLC7A11LMNAKDM4EDUSP3
SCHEMBL8630034 1.00 PTGS1 (0.41) PTGS1SLC7A11LMNAKDM4EDUSP3
SCHEMBL5712805 0.85 LMNA (0.43) LMNAKDM4EDUSP3MEN1KMT2A
SCHEMBL4617318 0.83 PTGS1 (0.38) PTGS1SLC7A11LMNAKDM4EDUSP3
SCHEMBL8941525 0.80 LMNA (0.40) LMNAKDM4EDUSP3MEN1KMT2A
SCHEMBL15392088 0.80 LMNA (0.47) LMNAKDM4EDUSP3MEN1KMT2A
SCHEMBL4862805 0.79 USP2 (0.44) PTGS1SLC7A11LMNAKDM4E
SCHEMBL9223741 0.79 USP2 (0.44) PTGS1SLC7A11LMNAKDM4E
SCHEMBL3031860 0.79 LMNA (0.44) PTGS1SLC7A11LMNAKDM4EDUSP3
SCHEMBL1824408 0.78 KDM4E (0.39) LMNAKDM4EDUSP3MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3728289-B1 OPTIMISED COMPOUNDS Axelia Oncology Pty Ltd (AU) 2025-09-10 EP disclosed
US-20250066416-A1 OPTIMISED COMPOUNDS THE UNIVERSITY OF MELBOURNE (AU) 2025-02-27 US disclosed
US-12195557-B2 Optimised compounds Axelia Oncology Pty Ltd (AU) 2025-01-14 US disclosed
CN-118161614-A Treatment of respiratory tract infections with TLR2 agonists 艾娜呼吸私人有限公司 2024-06-11 CN disclosed
EP-3600374-B1 TREATMENT OF RESPIRATORY INFECTION Ena Respiratory Pty Ltd (AU) 2024-05-15 EP disclosed
CN-110461351-B Treatment of respiratory tract infections with TLR2 agonists 艾娜呼吸私人有限公司 2024-03-26 CN disclosed
US-20210230217-A1 OPTIMISED COMPOUNDS Axelia Oncology Pty Ltd (AU) 2021-07-29 US disclosed
US-20210177795-A1 ADMINISTERING COMPOUNDS Axelia Oncology Pty Ltd (AU) 2021-06-17 US disclosed
EP-3727372-A1 ADMINISTRATION OF A TLR2 AGONIST FOR THE TREATMENT OR PREVENTION OF A RESPIRATORY CONDITION ASSOCIATED WITH AN INFECTIOUS AGENT Ena Therapeutics Pty Ltd (AU) 2020-10-28 EP disclosed
EP-3728289-A1 OPTIMISED COMPOUNDS Ena Therapeutics Pty Ltd (AU) 2020-10-28 EP disclosed
WO-2018176099-A1 TREATMENT OF RESPIRATORY INFECTION WITH A TLR2 AGONIST Ena Therapeutics Pty Ltd (AU) 2018-10-04 WO disclosed
US-9340622-B2 Synthetic immunogen useful for generating long lasting immunity and protection against pathogens COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-05-17 US disclosed
EP-2616098-B1 A SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS COUNCIL SCIENT IND RES (IN) 2016-04-20 EP disclosed
CN-103402539-B A kind of for generation of the lasting immunity of enantiopathy substance and the synthetic immunogen of protection COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-02-24 CN disclosed
CN-103402539-A A synthetic immunogen useful for generating long lasting immunity and protection against pathogens COUNCIL SCIENT IND RES 2013-11-20 CN disclosed
US-8569823-B2 Semiconductor device and manufacturing method thereof KABUSHIKI KAISHA TOSHIBA (JP) 2013-10-29 US disclosed
EP-2616098-A2 A SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS Council of Scientific & Industrial Research (IN) 2013-07-24 EP disclosed
US-20130183377-A1 SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS UNIVERSITY OF MELBOURNE (AU) 2013-07-18 US disclosed
US-20120068250-A1 SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF TOSHIBA MEMORY CORPORATION (JP) 2012-03-22 US disclosed
WO-2012035558-A2 A SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2012-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210230217-A1 OPTIMISED COMPOUNDS TLR2, TLR3, TLR1 PTGS1 1521/4885SLC7A11 3810/4885LMNA 3226/4885
US-20250066416-A1 OPTIMISED COMPOUNDS TLR2, TLR3, TLR1 PTGS1 1521/4885SLC7A11 3810/4885LMNA 3226/4885
US-12195557-B2 Optimised compounds TLR2, TLR3, TLR1 PTGS1 1521/4885SLC7A11 3810/4885LMNA 3226/4885
US-20130183377-A1 SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS CD4, TLR2, CD74 PTGS1 1222/4885SLC7A11 961/4885LMNA 1833/4885
US-20210177795-A1 ADMINISTERING COMPOUNDS TLR2, TLR3, TLR5 PTGS1 491/4885SLC7A11 3217/4885LMNA 3000/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.