SCHEMBL788466

SCHEMBL788466

Cc1cc(C)c(-c2cccc3c2sc2c(-c4ccc5[nH]c6ccc(-c7cccc8c7sc7c(-c9c(C)cc(C)cc9C)cccc78)cc6c5c4)cccc23)c(C)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.40
TLR9 Q9NR96 2/20 0.34
TLR8 Q9NR97 2/20 0.34
TLR7 Q9NYK1 2/20 0.34
ABCB1 P08183 1/20 0.33
CRHR1 P34998 2/20 0.33
TRPA1 O75762 1/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
POLB P06746 1/20 0.33
KMT2A Q03164 1/20 0.33
KIF11 P52732 1/20 0.33
WEE1 P30291 2/20 0.32
CHEK1 O14757 1/20 0.32
TDO2 P48775 1/20 0.32
PARP1 P09874 1/20 0.32
GRIA1 P42261 1/20 0.32
CACNG8 Q8WXS5 1/20 0.32
PIM1 P11309 1/20 0.32
PIM2 Q9P1W9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10227360 0.96 ALOX5 (0.40) ALOX5ABCB1MEN1NPC1POLB
SCHEMBL10226925 0.88 ALOX5 (0.51) ALOX5ABCB1TRPA1MEN1NPC1
SCHEMBL10225909 0.86 ALOX5 (0.43) ALOX5TLR9TLR8TLR7TRPA1
SCHEMBL788191 0.86 ALOX5 (0.43) ALOX5TLR9TLR8TLR7MEN1
SCHEMBL10227362 0.83 KIF11 (0.46) ALOX5MEN1NPC1POLBKMT2A
SCHEMBL788889 0.83 ALOX5 (0.44) ALOX5TRPA1MEN1NPC1POLB
SCHEMBL10225913 0.80 ALOX5 (0.49) ALOX5MEN1KMT2AWEE1TDO2
SCHEMBL787921 0.80 ALOX5 (0.46) ALOX5PIM1KDM4E
SCHEMBL788612 0.79 ALOX5 (0.48) ALOX5MEN1KMT2AWEE1CHEK1
SCHEMBL787205 0.79 ALOX5 (0.37) ALOX5TLR9TLR8TLR7ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 ALOX5 1162/4885TLR9 3566/4885TLR8 3322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.