Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9274565 | 0.90 | PDE7A (0.57) | HPGDL3MBTL1PDE7AMEN1KMT2A | |
| SCHEMBL3839379 | 0.89 | PDE7A (0.53) | HPGDL3MBTL1GAAPDE7AMEN1 | |
| SCHEMBL10501592 | 0.86 | HPGD (0.50) | HPGDL3MBTL1GAAPDE7AMEN1 | |
| SCHEMBL4111651 | 0.84 | HPGD (0.60) | HPGDL3MBTL1GAAMEN1KMT2A | |
| SCHEMBL640965 | 0.82 | HPGD (0.73) | HPGDL3MBTL1GAAPDE7AMEN1 | |
| SCHEMBL30392319 | 0.82 | HPGD (0.73) | HPGDL3MBTL1GAAPDE7AMEN1 | |
| SCHEMBL8091743 | 0.80 | HPGD (0.60) | HPGDL3MBTL1GAAPDE7AMEN1 | |
| SCHEMBL16296010 | 0.80 | HPGD (0.73) | HPGDL3MBTL1GAAPDE7AMEN1 | |
| SCHEMBL9400066 | 0.79 | PDE7A (0.55) | HPGDPDE7AMEN1KMT2AMAPK1 | |
| SCHEMBL3149944 | 0.79 | L3MBTL1 (0.72) | HPGDL3MBTL1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1065245-C | Substituted tetracyclic oxazepine and thiazepine derivatives having affinity for 5-HT2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2001-05-02 | — | — | CN | disclosed |
| EP-0789702-B1 | SUBSTITUTED TETRACYCLIC OXAZEPINE AND THIAZEPINE DERIVATIVES WITH 5-HT2 RECEPTOR AFFINITY | JANSSEN PHARMACEUTICA NV (BE) | 2001-02-07 | — | — | EP | disclosed |
| US-5773433-A | ANXIOLYTICS AND ANTIDEPRESSANTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1998-06-30 | — | — | US | disclosed |
| CN-1162314-A | Substituted tetraazazepine * and thiaza * derivatives having affinity for the 5-HT2 receptor | JANSSEN PHARMACEUTICA NV (BE) | 1997-10-15 | — | — | CN | disclosed |
| EP-0789702-A1 | SUBSTITUTED TETRACYCLIC OXAZEPINE AND THIAZEPINE DERIVATIVES WITH 5-HT2 RECEPTOR AFFINITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-08-20 | — | — | EP | disclosed |
| WO-1996014321-A1 | SUBSTITUTED TETRACYCLIC OXAZEPINE AND THIAZEPINE DERIVATIVES WITH 5-HT2 RECEPTOR AFFINITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-17 | — | — | WO | disclosed |
| US-5461046-A | Analgesics | G. D. SEARLE & CO. (US) | 1995-10-24 | — | — | US | disclosed |
| US-5304644-A | 1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain | G. D. SEARLE & CO. (US) | 1994-04-19 | — | — | US | disclosed |