Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRE11 | P49959 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RAPGEF3 | O95398 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7887157 | 0.86 | MRE11 (0.39) | MRE11MEN1KMT2AALOX12MAPT | |
| SCHEMBL6453911 | 0.80 | RAPGEF3 (0.39) | MRE11MEN1KMT2AALOX12MAPT | |
| SCHEMBL6453906 | 0.80 | RAPGEF3 (0.39) | MRE11MEN1KMT2AALOX12MAPT | |
| SCHEMBL7888535 | 0.77 | MEN1 (0.50) | MEN1KMT2AMAPTMAPK1LMNA | |
| SCHEMBL7705459 | 0.71 | LOXL2 (0.48) | MEN1KMT2AMAPTMAPK1LMNA | |
| SCHEMBL22632458 | 0.69 | MEN1 (0.48) | MEN1KMT2AALOX12MAPTRAPGEF3 | |
| SCHEMBL22632459 | 0.69 | MEN1 (0.48) | MEN1KMT2AALOX12MAPTRAPGEF3 | |
| SCHEMBL16291927 | 0.67 | MAPT (0.58) | MEN1KMT2AALOX12MAPTMAPK1 | |
| SCHEMBL16291929 | 0.67 | MAPT (0.58) | MEN1KMT2AALOX12MAPTMAPK1 | |
| SCHEMBL10421410 | 0.67 | MEN1 (0.50) | MEN1KMT2AALOX12MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114046-A1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | Janssen Pharmaceutica N.V. (BE) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017195-A1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-03-30 | — | — | WO | disclosed |