Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF3 | O95398 | 11/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | MRE11 | P49959 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6453911 | 1.00 | RAPGEF3 (0.39) | RAPGEF3RAPGEF4MAPTMAPK1MEN1 | |
| SCHEMBL7887153 | 0.80 | MRE11 (0.40) | RAPGEF3RAPGEF4MAPTMAPK1MEN1 | |
| SCHEMBL7887157 | 0.80 | MRE11 (0.39) | RAPGEF3RAPGEF4MAPTMAPK1MEN1 | |
| SCHEMBL6465506 | 0.77 | MEN1 (0.48) | MAPTMAPK1MEN1KMT2ALMNA | |
| SCHEMBL10421616 | 0.72 | ALOX12 (0.50) | RAPGEF3RAPGEF4MAPTMEN1KMT2A | |
| SCHEMBL10421615 | 0.72 | ALOX12 (0.50) | RAPGEF3RAPGEF4MAPTMEN1KMT2A | |
| SCHEMBL6455740 | 0.71 | ALDH1A1 (0.46) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL22632458 | 0.71 | MEN1 (0.48) | RAPGEF3RAPGEF4MAPTMEN1KMT2A | |
| SCHEMBL22632459 | 0.71 | MEN1 (0.48) | RAPGEF3RAPGEF4MAPTMEN1KMT2A | |
| SCHEMBL10421664 | 0.70 | ALOX12 (0.48) | RAPGEF3RAPGEF4MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894046-B2 | IL-5 inhibiting 6-azauracil derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-17 | — | — | US | disclosed |
| EP-1114046-B1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-23 | — | — | EP | disclosed |
| EP-0987265-A1 | Interleukin-5 inhibiting 6-azauracil derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-03-22 | — | — | EP | disclosed |