Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
| ▸ | SENP5 | Q96HI0 | 3/20 | 0.47 |
| ▸ | SENP2 | Q9HC62 | 3/20 | 0.47 |
| ▸ | SENP1 | Q9P0U3 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207378 | 0.92 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2GRIN2CACKR3 | |
| SCHEMBL7889384 | 0.89 | ALDH1A1 (0.56) | ALDH1A1MAPTSMN1; SMN2ACKR3SENP5 | |
| SCHEMBL8209703 | 0.87 | ALDH1A1 (0.56) | ALDH1A1MAPTSMN1; SMN2ACKR3SENP5 | |
| SCHEMBL7889265 | 0.86 | GRIN2C (0.60) | ALDH1A1MAPTSMN1; SMN2GRIN2CMEN1 | |
| SCHEMBL7424534 | 0.82 | MAPT (0.47) | ALDH1A1MAPTSMN1; SMN2ACKR3SENP5 | |
| Bicarbonate SCHEMBL7424539 | 0.81 | POLB (0.47) | ALDH1A1MAPTSMN1; SMN2ACKR3MEN1 | |
| SCHEMBL8206839 | 0.80 | MAPT (0.49) | ALDH1A1MAPTSMN1; SMN2ACKR3SENP5 | |
| SCHEMBL8210314 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2ACKR3SENP5 | |
| SCHEMBL8210426 | 0.80 | ACKR3 (0.53) | ALDH1A1MAPTACKR3MEN1KMT2A | |
| SCHEMBL7893018 | 0.80 | NR1H4 (0.56) | ALDH1A1MAPTSMN1; SMN2GRIN2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934301-B1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |