Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2C | Q14957 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7890828 | 0.91 | ALDH1A1 (0.52) | GRIN2CALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL8206984 | 0.90 | ALDH1A1 (0.54) | GRIN2CALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL7890829 | 0.90 | GRIN2C (0.56) | GRIN2CALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL7888439 | 0.89 | GRIN2C (0.57) | GRIN2CALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL7889261 | 0.86 | ALDH1A1 (0.55) | GRIN2CALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL7888341 | 0.86 | NR1H4 (0.50) | ALDH1A1MAPTKMT2ASMN1; SMN2RAB9A | |
| SCHEMBL7893018 | 0.84 | NR1H4 (0.56) | GRIN2CALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL7886983 | 0.84 | NR1H4 (0.51) | ALDH1A1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL8210425 | 0.84 | EPHX2 (0.51) | ALDH1A1MAPTKMT2ASMN1; SMN2NR1H4 | |
| SCHEMBL8207751 | 0.84 | TDP1 (0.56) | GRIN2CALDH1A1MAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934301-B1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |