Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 2/20 | 0.49 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207643 | 0.92 | MGAM (0.51) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8200088 | 0.85 | FLT3 (0.44) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8206432 | 0.84 | TAAR1 (0.54) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8208116 | 0.84 | MAPT (0.50) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8206343 | 0.83 | MAPT (0.47) | ALDH1A1MAPTHPGDSMN1; SMN2TDP1 | |
| SCHEMBL8199988 | 0.78 | ALDH1A1 (0.37) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8212479 | 0.78 | MAPT (0.38) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8207755 | 0.78 | GRIN2C (0.48) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8200038 | 0.77 | NPC1 (0.37) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL7888385 | 0.77 | MGAM (0.73) | KMT2AMEN1RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934301-B1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | EP | claimed |
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | claimed |
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |