Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 18/20 | 0.49 |
| ▸ | CASP6 | P55212 | 16/20 | 0.49 |
| ▸ | CASP8 | Q14790 | 16/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78931 | 1.00 | CASP3 (0.49) | CASP3CASP6CASP8CASP7CASP1 | |
| SCHEMBL78930 | 1.00 | CASP3 (0.49) | CASP3CASP6CASP8CASP7CASP1 | |
| SCHEMBL13792175 | 1.00 | CASP3 (0.49) | CASP3CASP6CASP8CASP7CASP1 | |
| SCHEMBL3579369 | 0.91 | CASP1 (0.48) | CASP3CASP6CASP8CASP7CASP1 | |
| SCHEMBL79920 | 0.91 | CASP1 (0.48) | CASP3CASP6CASP8CASP7CASP1 | |
| SCHEMBL79919 | 0.91 | CASP1 (0.48) | CASP3CASP6CASP8CASP7CASP1 | |
| SCHEMBL79918 | 0.91 | CASP1 (0.48) | CASP3CASP6CASP8CASP7CASP1 | |
| SCHEMBL3574565 | 0.90 | CASP3 (0.40) | CASP3CASP6CASP8CASP7CASP1 | |
| SCHEMBL3574570 | 0.90 | CASP3 (0.40) | CASP3CASP6CASP8CASP7CASP1 | |
| SCHEMBL3574567 | 0.90 | CASP3 (0.40) | CASP3CASP6CASP8CASP7CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129381-B2 | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090281128-A1 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| US-7553852-B2 | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-06-30 | — | — | US | disclosed |
| US-20040072850-A1 | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072850-A1 | Caspase inhibitors and uses thereof | CASP1, CASP5, CASP2 | CASP3 4/4885CASP6 8/4885CASP8 10/4885 |
| US-20090281128-A1 | CASPASE INHIBITORS AND USES THEREOF | CASP1, CASP5, CASP3 | CASP3 3/4885CASP6 7/4885CASP8 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.