Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7894146 | 0.91 | AADAT (0.34) | AADAT | |
| SCHEMBL7895781 | 0.86 | GSK3B (0.37) | AADATGSK3B | |
| SCHEMBL7896987 | 0.85 | AADAT (0.31) | AADATALDH1A1 | |
| SCHEMBL7886033 | 0.85 | ALDH1A1 (0.34) | AADATALDH1A1 | |
| SCHEMBL7896926 | 0.84 | NPC1 (0.34) | CES2CES1AADATALDH1A1GSK3B | |
| SCHEMBL7893678 | 0.84 | AADAT (0.33) | AADAT | |
| SCHEMBL7894079 | 0.84 | MEN1 (0.35) | AADATLMNA | |
| SCHEMBL7893527 | 0.83 | GSK3B (0.35) | AADATALDH1A1LMNAGSK3B | |
| SCHEMBL7893806 | 0.83 | UCHL3 (0.32) | AADAT | |
| SCHEMBL7895796 | 0.83 | ALDH1A1 (0.34) | AADATALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174883-B1 | ENZYME INHIBITORS OF PROSTAGLANDIN H2 SYNTHASE, 5-LIPOXYGENASE; INHIBITORS OF INTERLEUKIN-1 BIOSYNTHESIS; ANALGESICS; ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS; BONE, CONNECTIVE TISSUE METABOLISM AND SKIN DISORDERS | PFIZER INC. | 2001-01-16 | — | — | US | disclosed |
| US-5919809-A | 3-substituted-2-oxindole derivatives | PFIZER INC. (US) | 1999-07-06 | — | — | US | disclosed |
| EP-0393936-B1 | 3-substituted-2-oxindole derivatives as antiinflammatory agents | PFIZER (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5300655-A | 2-carboxy-thiophene derivatives | PFIZER INC. (US) | 1994-04-05 | — | — | US | disclosed |
| US-5290802-A | 3-substituted-2-oxindole derivatives | PFIZER INC. (US) | 1994-03-01 | — | — | US | disclosed |
| US-5047554-A | 3-substituted-2-oxindole derivatives | PFIZER INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0393936-A1 | 3-substituted-2-oxindole derivatives as antiinflammatory agents | PFIZER INC. (US) | 1990-10-24 | — | — | EP | disclosed |