Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860356 | 0.86 | ALPL (0.53) | ALPLALDH1A1KDM4EDGAT1BRAF | |
| SCHEMBL29556839 | 0.84 | ALPL (0.56) | ALPLPDGFRBKDRHPGDPIK3CG | |
| SCHEMBL790824 | 0.84 | ALPL (0.56) | ALPLPDGFRBKDRHPGDPIK3CG | |
| SCHEMBL798867 | 0.84 | ALPL (0.48) | ALPLDGAT1PDGFRBKDRPIK3CG | |
| SCHEMBL789687 | 0.82 | ALPL (0.47) | ALPLDGAT1BRAFPDGFRBKDR | |
| SCHEMBL109782 | 0.81 | ALPL (0.52) | ALPLPIK3CG | |
| SCHEMBL789976 | 0.81 | ALPL (0.46) | ALPLDGAT1PDGFRBKDRCYP17A1 | |
| SCHEMBL790434 | 0.79 | ALPL (0.54) | ALPLBRAFPDGFRBKDRCYP17A1 | |
| SCHEMBL23275716 | 0.79 | KDM4E (0.44) | ALPLALDH1A1KDM4EDGAT1PDGFRB | |
| SCHEMBL30333038 | 0.78 | ALPL (0.58) | ALPLBRAFPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |