SCHEMBL7894407

SCHEMBL7894407

O=C(O)C1C=CCC1N1C(=O)c2ccccc2C1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.38
CA12 O43570 2/20 0.38
CA9 Q16790 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.36
EDNRB P24530 1/20 0.36
EDNRA P25101 1/20 0.36
ALDH1A1 P00352 3/20 0.36
SMO Q99835 1/20 0.36
CHRM2 P08172 1/20 0.36
OPRM1 P35372 1/20 0.36
DDB1 Q16531 1/20 0.36
CRBN Q96SW2 1/20 0.36
IKZF3 Q9UKT9 1/20 0.36
CYP1A2 P05177 1/20 0.36
TSHR P16473 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
SCN2A Q99250 2/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
POLB P06746 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7895358 0.82 L3MBTL1 (0.39) HDAC4L3MBTL1ALDH1A1KMT2ACYP2C19
SCHEMBL2147841 0.73 CA12 (0.42) CA12CA9L3MBTL1ALDH1A1SMO
SCHEMBL25225543 0.73 ABAT (0.42) CA12CA9L3MBTL1ALDH1A1CHRM2
SCHEMBL31320422 0.73 ABAT (0.42) CA12CA9L3MBTL1ALDH1A1CHRM2
SCHEMBL15276739 0.71 CYP2C19 (0.45) L3MBTL1ALDH1A1CHRM2OPRM1DDB1
SCHEMBL14811673 0.71 CYP2C19 (0.45) L3MBTL1ALDH1A1CHRM2OPRM1DDB1
SCHEMBL11040612 0.69 ALDH1A1 (0.38) CA12CA9L3MBTL1ALDH1A1CHRM2
SCHEMBL11040609 0.69 ALDH1A1 (0.38) CA12CA9L3MBTL1ALDH1A1CHRM2
SCHEMBL7537535 0.69 ALDH1A1 (0.43) CA12CA9L3MBTL1ALDH1A1SMO
SCHEMBL19533902 0.69 ALDH1A1 (0.43) CA12CA9L3MBTL1ALDH1A1SMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6180611-B1 INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR DARWIN DISCOVERY, LTD. (GB) 2001-01-30 US disclosed
US-5994312-A Peptidyl compounds DARWIN DISCOVERY, LTD. (GB) 1999-11-30 US disclosed
EP-0784629-A1 PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES Chiroscience Limited (GB) 1997-07-23 EP disclosed
WO-1996011209-A1 PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES CHIROSCIENCE LIMITED (GB) 1996-04-18 WO disclosed