Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720417 | 0.81 | HDAC3 (0.41) | HDAC3HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL2299342 | 0.76 | KMT2A (0.44) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL14720415 | 0.71 | DRD2 (0.38) | POLBRAB9AMEN1KMT2ALMNA | |
| SCHEMBL3830768 | 0.70 | NQO2 (0.32) | POLBMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3915360 | 0.70 | NQO2 (0.32) | POLBMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15064459 | 0.69 | KDM4E (0.57) | HDAC3HDAC1HDAC2POLBMEN1 | |
| SCHEMBL12474426 | 0.68 | HDAC3 (0.50) | HDAC3HDAC1HDAC2LMNAGAA | |
| SCHEMBL15064415 | 0.66 | HDAC3 (0.45) | HDAC3HDAC1HDAC2POLBKMT2A | |
| SCHEMBL15064460 | 0.66 | HDAC3 (0.43) | HDAC3HDAC1HDAC2POLBCTDSP1 | |
| SCHEMBL5630219 | 0.65 | HDAC3 (0.62) | HDAC3HDAC1HDAC2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616071-A2 | FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037299-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |