Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885318 | 0.93 | TSHR (0.76) | TSHRGLAGAALMNAMEN1 | |
| SCHEMBL7892606 | 0.88 | MEN1 (0.74) | TSHRGLAGAASMN1; SMN2MEN1 | |
| SCHEMBL7894987 | 0.83 | GAA (0.82) | TSHRGAALMNAALDH1A1POLB | |
| SCHEMBL7896220 | 0.83 | MAPT (0.71) | TSHRGAAUSP2LMNASMN1; SMN2 | |
| SCHEMBL7885173 | 0.81 | GAA (0.59) | TSHRGLAGAAUSP2LMNA | |
| SCHEMBL10700300 | 0.81 | ADRA1A (0.55) | TSHRGLAUSP2LMNASMN1; SMN2 | |
| SCHEMBL15478270 | 0.77 | TSHR (0.82) | TSHRGLASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7893043 | 0.76 | KMT2A (0.73) | TSHRGAAUSP2SMN1; SMN2MEN1 | |
| SCHEMBL17767008 | 0.76 | SMN1; SMN2 (0.81) | GAASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL32664309 | 0.76 | TSHR (0.66) | TSHRGLAGAASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180629-B1 | INDUCING OR PROMOTING APOPTOSIS AND FOR ARRESTING UNCONTROLLED NEOPLASTIC CELL PROLIFERATION, INCLUDING PRECANCEROUS AND CANCEROUS LESIONS | CELL PATHWAYS, INC. | 2001-01-30 | — | — | US | disclosed |