Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304279 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL9494082 | 0.94 | ALDH1A1 (0.52) | ALDH1A1TDP1HSD17B10CTSDTGM2 | |
| SCHEMBL31153234 | 0.82 | ALDH1A1 (0.35) | ALDH1A1TGM2LMNA | |
| Vinylsulfonic Acid SCHEMBL8060920 | 0.80 | ALDH1A1 (0.45) | ALDH1A1TDP1TGM2TSHRL3MBTL1 | |
| SCHEMBL28259050 | 0.80 | MAOA (0.42) | ALDH1A1TDP1TGM2PTGS2IDO1 | |
| SCHEMBL19175924 | 0.77 | ALDH1A1 (0.50) | ALDH1A1TDP1HSD17B10TSHRMAPK1 | |
| Cinnamaldehyde SCHEMBL27153513 | 0.76 | ALDH1A1 (0.64) | ALDH1A1MAPK1LMNASMN1; SMN2NPC1 | |
| SCHEMBL2518539 | 0.76 | ALDH1A1 (0.50) | ALDH1A1TDP1HSD17B10CTSDTGM2 | |
| SCHEMBL39287 | 0.74 | MAPK13 (0.60) | ALDH1A1TDP1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL223592 | 0.73 | ALDH1A1 (0.60) | ALDH1A1TDP1HSD17B10CTSDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105585708-B | Nylon composite materials of nanometer enhancing particulate reinforcement and its preparation method and application | 广东新会美达锦纶股份有限公司 | 2018-07-03 | — | — | CN | claimed |
| CN-1326330-A | Therapeutic use of polymers | BIOCOMPATIBLES LTD (GB) | 2001-12-12 | — | — | CN | disclosed |
| EP-1141124-A1 | ANIONIC-CATIONIC POLYION COMPLEXES COMPRISING ZWITTERIONIC MONOMER COMPONENT | BIOCOMPATIBLES LTD. (GB) | 2001-10-10 | — | — | EP | disclosed |
| EP-1128784-A1 | THERAPEUTIC USE OF POLYMERS | BIOCOMPATIBLES LTD. (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000029481-A1 | ANIONIC-CATIONIC POLYION COMPLEXES COMPRISING ZWITTERIONIC MONOMER COMPONENT | BIOCOMPATIBLES LIMITED (GB) | 2000-05-25 | — | — | WO | disclosed |
| WO-2000028920-A1 | THERAPEUTIC USE OF POLYMERS | BIOCOMPATIBLES LIMITED (GB) | 2000-05-25 | — | — | WO | disclosed |