Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28413796 | 0.84 | FPR2 (0.47) | HSP90AA1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3582565 | 0.79 | FPR2 (0.43) | KMT2AKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL27228604 | 0.76 | HSP90AA1 (0.46) | HSP90AA1KMT2AMEN1ALDH1A1 | |
| SCHEMBL12603635 | 0.76 | RAB9A (0.47) | HSP90AA1KMT2ARAB9AL3MBTL1MEN1 | |
| SCHEMBL13310544 | 0.75 | FPR2 (0.40) | HSP90AA1HSP90AB1HSP90B1KMT2ARAB9A | |
| SCHEMBL1723554 | 0.74 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1HSP90B1KMT2AMEN1 | |
| SCHEMBL22356858 | 0.73 | FPR2 (0.39) | HSP90AA1HSP90AB1HSP90B1SMN1; SMN2FPR2 | |
| SCHEMBL31461544 | 0.73 | FPR2 (0.44) | HSP90AA1HSP90AB1HSP90B1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL4053167 | 0.72 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HSP90B1KMT2AL3MBTL1 | |
| SCHEMBL2960305 | 0.72 | ALPL (0.50) | KMT2AL3MBTL1MEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708776-B1 | ANTIALLERGIC IMIDAZOAZEPINES | JANSSEN PHARMACEUTICA NV (BE) | 2001-01-03 | — | — | EP | disclosed |
| US-5674866-A | Antiallergic imidazoazepines | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-10-07 | — | — | US | disclosed |