Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | S100A9 | P06702 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17969358 | 0.85 | HPGD (0.44) | S100A9PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15653017 | 0.83 | CYP17A1 (0.41) | CYP17A1S100A9LRRK2PIK3CAPIK3CD | |
| SCHEMBL791104 | 0.83 | MAPT (0.48) | CYP17A1S100A9LRRK2PIK3CAPIK3CD | |
| SCHEMBL790767 | 0.82 | PTGS1 (0.45) | S100A9MEN1POLBKMT2ASLC22A12 | |
| SCHEMBL16551863 | 0.81 | PIK3CA (0.47) | CYP17A1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL29556703 | 0.79 | PIK3CD (0.52) | PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL114826 | 0.79 | PIK3CD (0.52) | PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL3117652 | 0.78 | PIK3CG (0.44) | S100A9PIK3CAPIK3CDPIK3CGPIK3CB | |
| Ammonia Solution, Strong SCHEMBL28553362 | 0.77 | PIK3CD (0.51) | PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL789611 | 0.77 | ALDH1A1 (0.52) | CYP17A1PIK3CGBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958564-B1 | HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS | CALITOR SCIENCES LLC (US) | 2018-05-09 | — | — | EP | disclosed |
| US-9573953-B2 | Heteroaromatic compounds as PI3 kinase modulators and methods of use | CALITOR SCIENCES, LLC (US) | 2017-02-21 | — | — | US | disclosed |
| EP-2958564-A1 | HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS | Calitor Sciences, LLC (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130375-A1 | HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS | CALITOR SCIENCES, LLC (US) | 2014-08-28 | — | — | WO | disclosed |
| US-20140234254-A1 | HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-08-21 | — | — | US | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140234254-A1 | HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE | PIK3R1, PIK3R3, AKT3 | CYP17A1 1380/4885S100A9 4675/4885LRRK2 699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.