Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | S100A9 | P06702 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17969358 | 0.86 | HPGD (0.44) | MAPTBRAFPIK3CDPIK3CAPIK3CG | |
| SCHEMBL3117652 | 0.85 | PIK3CG (0.44) | PIK3CDPIK3CAPIK3CGPIK3CBMEN1 | |
| SCHEMBL789716 | 0.83 | CYP17A1 (0.42) | BRAFCYP17A1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL16551863 | 0.82 | PIK3CA (0.47) | BRAFCYP17A1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL114826 | 0.80 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL29556703 | 0.80 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| Ammonia Solution, Strong SCHEMBL28553362 | 0.79 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL789611 | 0.78 | ALDH1A1 (0.52) | BRAFCYP17A1PIK3CG | |
| SCHEMBL16913931 | 0.76 | PIK3C3 (0.52) | BRAFPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL789687 | 0.76 | ALPL (0.47) | MAPTBRAFCYP2C9CYP17A1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |