Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.63 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.63 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448820 | 0.86 | CHRNB4 (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL19618884 | 0.86 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL3113146 | 0.86 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL17955434 | 0.86 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL11457902 | 0.82 | PIM1 (0.45) | CHRNB4CHRNA3LTA4H | |
| SCHEMBL30785484 | 0.82 | LTA4H (0.51) | CHRNB4CHRNA3LTA4H | |
| SCHEMBL5260158 | 0.81 | CHRNB4 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL2202866 | 0.81 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL2202872 | 0.81 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL25186844 | 0.78 | CTSS (0.47) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053165-A1 | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators | PFIZER INC. (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053165-A1 | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators | PFIZER INC. (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2010100606-A1 | NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053165-A1 | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators | BACE1, BACE2, PSEN1 | CHRNB4 139/4885CHRNA3 121/4885CHRNB2 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.