Known targets — ChEMBL curated mechanism
POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2
The experimentally established mechanism targets of Aceneuramic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | ST6GAL1 | P15907 | 8/20 | 0.43 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aceneuramic Acid SCHEMBL2302895 | 0.97 | LMNA (0.58) | LMNATHRBMTORMDM2NCOA1 | |
| Aceneuramic Acid SCHEMBL237563 | 0.92 | TSHR (0.51) | TSHRGLAST6GAL1P2RY2 | |
| Cytarabine SCHEMBL4938656 | 0.79 | LMNA (0.71) | LMNATHRBMTORMDM2NCOA1 | |
| Cytidine SCHEMBL27959710 | 0.79 | LMNA (0.67) | LMNATHRBMTORMDM2NCOA1 | |
| Cytidine SCHEMBL27959720 | 0.79 | LMNA (0.67) | LMNATHRBMTORMDM2NCOA1 | |
| Cytidine SCHEMBL28813592 | 0.78 | LMNA (0.72) | LMNATHRBMTORMDM2NCOA1 | |
| Cytarabine SCHEMBL9007590 | 0.78 | LMNA (0.90) | LMNATHRBMTORMDM2NCOA1 | |
| Cytarabine SCHEMBL458337 | 0.78 | LMNA (0.90) | LMNATHRBMTORMDM2NCOA1 | |
| Cytarabine SCHEMBL285195 | 0.78 | LMNA (0.90) | LMNATHRBMTORMDM2NCOA1 | |
| Cytidine SCHEMBL39902 | 0.78 | LMNA (0.90) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187754-B1 | Sialyl-Lewisa and sialyl-Lewisx epitode analogues | GLYCOTECH CORP. | 2001-02-13 | — | — | US | claimed |