SCHEMBL7897832

SCHEMBL7897832

CC(C)C[C@H](NC(=O)C1CCCC1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.56
KMT2A Q03164 3/20 0.56
MEN1 O00255 2/20 0.56
LMNA P02545 2/20 0.56
TSHR P16473 2/20 0.52
PSMB5 P28074 5/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
GAA P10253 1/20 0.50
ALOX15 P16050 1/20 0.50
MAPK1 P28482 1/20 0.49
MAPT P10636 1/20 0.49
FOLH1 Q04609 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
KDM4E B2RXH2 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9832137 1.00 ALDH1A1 (0.56) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL6562939 0.98 ALDH1A1 (0.54) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL8581694 0.98 ALDH1A1 (0.54) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL9829273 0.98 ALDH1A1 (0.54) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL7896986 0.98 ALDH1A1 (0.54) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL6561332 0.97 TSHR (0.53) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL25045739 0.97 KMT2A (0.56) ALDH1A1KMT2AMEN1LMNATSHR
Benzene SCHEMBL28226142 0.95 PSMB5 (0.55) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL7898101 0.93 ALDH1A1 (0.58) ALDH1A1KMT2AMEN1LMNATSHR
SCHEMBL1951893 0.93 ALDH1A1 (0.58) ALDH1A1KMT2AMEN1LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230374143-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS VESPER BIO APS (DK) 2023-11-23 US claimed
EP-4225280-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS Insusense ApS (DK) 2023-08-16 EP claimed
CN-116194096-A Sortilin antagonists for preventing and treating hearing impairment 因苏森斯有限公司 2023-05-30 CN claimed
WO-2022074119-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS INSUSENSE ApS (DK) 2022-04-14 WO claimed
EP-3981394-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS. Insusense ApS (DK) 2022-04-13 EP claimed
US-20230374143-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS VESPER BIO APS (DK) 2023-11-23 US disclosed
US-20230374143-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS VESPER BIO APS (DK) 2023-11-23 US disclosed
US-20230374143-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS VESPER BIO APS (DK) 2023-11-23 US disclosed
EP-4225280-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS Insusense ApS (DK) 2023-08-16 EP disclosed
CN-116194096-A Sortilin antagonists for preventing and treating hearing impairment 因苏森斯有限公司 2023-05-30 CN disclosed
WO-2022074119-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS INSUSENSE ApS (DK) 2022-04-14 WO disclosed
EP-3981394-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS. Insusense ApS (DK) 2022-04-13 EP disclosed
EP-0584374-B1 PEPTIDE WHICH INHIBITS PHOSPHOLIPASE C KYOWA HAKKO KOGYO KK (JP) 1997-09-24 EP disclosed
US-5629020-A Modified amino acids for drug delivery EMISPHERE TECHNOLOGIES, INC. (US) 1997-05-13 US disclosed
EP-0758843-A1 MODIFIED AMINO ACIDS FOR DRUG DELIVERY Emisphere Technologies, Inc. (US) 1997-02-26 EP disclosed
WO-1996021464-A1 COMPOSITIONS FOR THE DELIVERY OF ANTIGENS EMISPHERE TECHNOLOGIES, INC. (US) 1996-07-18 WO disclosed
WO-1995028838-A1 MODIFIED AMINO ACIDS FOR DRUG DELIVERY EMISPHERE TECHNOLOGIES, INC. (US) 1995-11-02 WO disclosed
EP-0226304-B1 COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC SANKYO COMPANY LIMITED (JP) 1991-08-28 EP disclosed
US-4757066-A Reduces renal toxicity SANKYO COMPANY LIMITED (JP) 1988-07-12 US disclosed
EP-0226304-A1 Composition containing a penem or carbapenem antibiotic SANKYO COMPANY LIMITED (JP) 1987-06-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230374143-A1 A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS SORT1, NTSR2, SLC17A5 ALDH1A1 1848/4885KMT2A 4676/4885MEN1 1693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.