Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790689 | 0.91 | ALPL (0.51) | ALPLL3MBTL1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL9954366 | 0.90 | ALPL (0.50) | ALPLALDH1A1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL14317978 | 0.90 | ALPL (0.50) | ALPLL3MBTL1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL9954690 | 0.82 | ALPL (0.57) | ALPLSMN1; SMN2PIK3CD | |
| SCHEMBL1502534 | 0.78 | ALPL (0.56) | ALPL | |
| SCHEMBL9954248 | 0.76 | ALPL (0.54) | ALPLMAPTTSHR | |
| SCHEMBL9953472 | 0.76 | ALPL (0.62) | ALPLL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL10289141 | 0.76 | MAPT (0.49) | L3MBTL1MAPTALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL16600189 | 0.75 | ALDH1A1 (0.44) | L3MBTL1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL31436962 | 0.75 | POLB (0.38) | ALDH1A1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |