Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 8/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.58 |
| ▸ | MTOR | P42345 | 7/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807155 | 0.92 | PIK3CG (0.62) | PI4KAPIK3CGPIK3CAMTORPIK3CD | |
| SCHEMBL789833 | 0.91 | PIK3CG (0.61) | PI4KAPIK3CGPIK3CAMTORPIK3CD | |
| Lithium SCHEMBL789835 | 0.91 | PIK3CG (0.61) | PI4KAPIK3CGPIK3CAMTORPIK3CD | |
| SCHEMBL790751 | 0.88 | PIK3CA (0.58) | PI4KAPIK3CGPIK3CAMTORPIK3CD | |
| SCHEMBL790763 | 0.86 | PIK3CG (0.62) | PI4KAPIK3CGPIK3CAMTORPIK3CD | |
| SCHEMBL807470 | 0.84 | PIK3CG (0.55) | PI4KAPIK3CGPIK3CAMTORPIK3CD | |
| SCHEMBL10274897 | 0.84 | PIK3CG (0.54) | PI4KAPIK3CGPIK3CAMTORPIK3CD | |
| SCHEMBL790028 | 0.84 | PI4KA (0.60) | PI4KAPIK3CGPIK3CAMTORPIK3CD | |
| Lithium Ion SCHEMBL789804 | 0.83 | PIK3CG (0.73) | PI4KAPIK3CGPIK3CAMTORPIK3CD | |
| SCHEMBL790228 | 0.82 | PI4KA (0.52) | PI4KAPIK3CGPIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |