Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464308 | 1.00 | POLB (0.53) | POLBHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL3965782 | 0.86 | POLB (0.67) | POLBHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7464430 | 0.85 | ALDH1A1 (0.55) | POLBHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7897428 | 0.85 | ALDH1A1 (0.55) | POLBHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL13698475 | 0.85 | POLB (0.65) | POLBHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7473599 | 0.82 | POLB (0.53) | POLBHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL25260 | 0.81 | GRIN2B (0.65) | MAPTALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL7464119 | 0.81 | POLB (0.49) | POLBHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL14529001 | 0.80 | L3MBTL3 (0.65) | POLBHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL26706266 | 0.80 | TSHR (0.60) | POLBHTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191130-B1 | HYPOTENSIVE AGENTS; THERAPY FOR SEXUAL DISORDERS; CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | PIERRE FABRE MEDICAMENT (FR) | 2001-02-20 | — | — | US | disclosed |