Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.77 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.77 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.77 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.77 |
| ▸ | HTR2A | P28223 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.77 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.77 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.77 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900185 | 0.91 | ABCC8 (0.64) | CYP3A4ABCC8LMNAMAPK1SLC22A1 | |
| SCHEMBL7895996 | 0.89 | CYP3A4 (0.73) | CYP3A4ABCC8LMNAMAPK1SLC22A1 | |
| Repaglinide SCHEMBL29373506 | 0.87 | ABCC8 (1.00) | CYP3A4ABCC8LMNAMAPK1SLC22A1 | |
| Repaglinide SCHEMBL29598841 | 0.87 | ABCC8 (1.00) | CYP3A4ABCC8LMNAMAPK1SLC22A1 | |
| SCHEMBL10013499 | 0.87 | ABCC8 (0.87) | CYP3A4ABCC8LMNAMAPK1SLC22A1 | |
| Repaglinide SCHEMBL163867 | 0.87 | ABCC8 (1.00) | CYP3A4ABCC8LMNAMAPK1SLC22A1 | |
| Repaglinide SCHEMBL1536902 | 0.87 | ABCC8 (1.00) | CYP3A4ABCC8LMNAMAPK1SLC22A1 | |
| SCHEMBL3008216 | 0.87 | LMNA (0.87) | CYP3A4ABCC8LMNAMAPK1SLC22A1 | |
| Repaglinide SCHEMBL8141950 | 0.87 | ABCC8 (1.00) | CYP3A4ABCC8LMNAMAPK1SLC22A1 | |
| Repaglinide SCHEMBL29392295 | 0.87 | ABCC8 (1.00) | CYP3A4ABCC8LMNAMAPK1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37035-E1 | HYPOGLYCEMIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-01-30 | — | — | US | disclosed |
| US-6143769-A | ENANTIOMORPH | KARL THOMAE GMBH (DE) | 2000-11-07 | — | — | US | disclosed |
| US-5312924-A | Compounds for lowering blood sugar and effecting metabolism | DR. KARL THOMAE GMBH (DE) | 1994-05-17 | — | — | US | disclosed |
| US-5216167-A | Hypoglycemic agents | DR. KARL THOMAE GMBH (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0208200-A1 | Phenylacetic-acid derivatives, pharmaceutical compositions containing them and processes for their production | Dr. Karl Thomae GmbH (DE) | 1987-01-14 | — | — | EP | disclosed |