Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 3/20 | 0.87 |
| ▸ | LMNA | P02545 | 3/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.87 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.87 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.87 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.87 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.87 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.87 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.87 |
| ▸ | HTR2A | P28223 | 1/20 | 0.87 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.87 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.87 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.87 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.87 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.87 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.87 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Repaglinide SCHEMBL16137 | 0.93 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| SCHEMBL2998276 | 0.93 | LMNA (0.87) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL29598841 | 0.93 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL29392295 | 0.93 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL8141950 | 0.93 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL29373506 | 0.93 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL1536902 | 0.93 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| SCHEMBL3008216 | 0.93 | LMNA (0.87) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL163867 | 0.93 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| SCHEMBL391046 | 0.92 | ABCC8 (0.85) | ABCC8LMNAMAPK1CYP3A4SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101769-B2 | Chemical intermediate; high purity drug | ACTAVIS GROUP PTC EHF (IE) | 2012-01-24 | — | — | US | disclosed |
| US-20080200684-A1 | Process for Preparing Ethyl (s)-2-Ethoxy-4-[N-[1-(2-Piperidinophenyl)-3-Methyl-1-Butyl]Aminocarbonyl Methyl]Benzoate and Use Thereof for the Preparation of Repaglinide | ACTAVIS GROUP PTC HF (IS) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200684-A1 | Process for Preparing Ethyl (s)-2-Ethoxy-4-[N-[1-(2-Piperidinophenyl)-3-Methyl-1-Butyl]Aminocarbonyl Methyl]Benzoate and Use Thereof for the Preparation of Repaglinide | MEP1B, GABRE, BPGM | ABCC8 3122/4885LMNA 2050/4885MAPK1 2031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.