Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.38 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16553952 | 1.00 | ALDH1A1 (0.46) | ALDH1A1HSD17B10PGRGAAPTGS1 | |
| SCHEMBL28544968 | 1.00 | ALDH1A1 (0.46) | ALDH1A1HSD17B10PGRGAAPTGS1 | |
| SCHEMBL789912 | 0.90 | ALDH1A1 (0.44) | ALDH1A1HSD17B10PGRGAAPTGS1 | |
| SCHEMBL15622672 | 0.88 | ALDH1A1 (0.47) | ALDH1A1HSD17B10PGRGAAPTGS1 | |
| SCHEMBL22582156 | 0.87 | ALDH1A1 (0.43) | ALDH1A1HSD17B10PGRGAAPTGS1 | |
| SCHEMBL12274119 | 0.87 | ALDH1A1 (0.43) | ALDH1A1HSD17B10PGRGAAPTGS1 | |
| SCHEMBL30628342 | 0.87 | ALDH1A1 (0.43) | ALDH1A1HSD17B10PGRGAAPTGS1 | |
| SCHEMBL790316 | 0.87 | ALDH1A1 (0.41) | ALDH1A1HSD17B10PGRGAAPTGS1 | |
| SCHEMBL790551 | 0.84 | MEN1 (0.41) | ALDH1A1HSD17B10PGRGAAPTGS1 | |
| SCHEMBL15765580 | 0.83 | ALDH1A1 (0.43) | ALDH1A1HSD17B10PGRGAAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252066-B1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2019-05-22 | — | — | EP | disclosed |
| EP-3252066-B1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2019-05-22 | — | — | EP | disclosed |
| US-20190085010-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2019-03-21 | — | — | US | disclosed |
| US-20190085010-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2019-03-21 | — | — | US | disclosed |
| US-10106571-B2 | HCV polymerase inhibitors | MEDIVIR AB (SE) | 2018-10-23 | — | — | US | disclosed |
| US-20180105549-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2018-04-19 | — | — | US | disclosed |
| US-20180105549-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2018-04-19 | — | — | US | disclosed |
| US-20180105549-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2018-04-19 | — | — | US | disclosed |
| EP-3252066-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2017-12-06 | — | — | EP | disclosed |
| US-9828408-B2 | HCV polymerase inhibitors | MEDIVIR AB (SE) | 2017-11-28 | — | — | US | disclosed |
| US-9278990-B2 | Substituted nucleotide analogs | ALIOS BIOPHARMA, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-20150175648-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2015-06-25 | — | — | US | disclosed |
| US-20150175648-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2015-06-25 | — | — | US | disclosed |
| US-20150175648-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2015-06-25 | — | — | US | disclosed |
| WO-2015056213-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015034420-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2015-03-12 | — | — | WO | disclosed |
| WO-2015034420-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2015-03-12 | — | — | WO | disclosed |
| US-20150038451-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | ALIOS BIOPHARMA, INC. | 2015-02-05 | — | — | US | disclosed |
| US-8871737-B2 | Substituted nucleotide analogs | ALIOS BIOPHARMA, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20120071434-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | ALIOS BIOPHARMA, INC. (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10106571-B2 | HCV polymerase inhibitors | POLI, POLB, POLL | ALDH1A1 445/4885HSD17B10 2009/4885PGR 2251/4885 |
| US-20190085010-A1 | HCV POLYMERASE INHIBITORS | POLI, POLB, POLL | ALDH1A1 445/4885HSD17B10 2009/4885PGR 2251/4885 |
| US-20180105549-A1 | HCV POLYMERASE INHIBITORS | POLI, POLB, POLL | ALDH1A1 445/4885HSD17B10 2009/4885PGR 2251/4885 |
| US-20120071434-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | PNP, NUDT1, TYMP | ALDH1A1 2567/4885HSD17B10 4536/4885PGR 2198/4885 |
| US-20150175648-A1 | HCV POLYMERASE INHIBITORS | POLI, POLB, POLL | ALDH1A1 445/4885HSD17B10 2009/4885PGR 2251/4885 |
| US-20150038451-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | PNP, NUDT1, TYMP | ALDH1A1 2567/4885HSD17B10 4536/4885PGR 2198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.