Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7697294 | 0.75 | CA12 (0.47) | JAK2TYK2DRD2DRD4WEE1 | |
| SCHEMBL1642543 | 0.73 | MKNK1 (0.60) | FGFR2FLT3MKNK1 | |
| SCHEMBL20117703 | 0.71 | ULK1 (0.39) | ULK1JAK2TYK2DRD2DRD4 | |
| SCHEMBL1641747 | 0.70 | FGFR2 (0.67) | FGFR2FLT3ULK1IGF1R | |
| SCHEMBL29393606 | 0.69 | CDK1 (0.49) | FGFR2FLT3MKNK1 | |
| SCHEMBL1642894 | 0.68 | EGFR (0.56) | FGFR2FLT3MKNK1 | |
| SCHEMBL13154269 | 0.68 | SYK (0.40) | JAK2TYK2 | |
| SCHEMBL12065998 | 0.68 | EGFR (0.52) | — | |
| SCHEMBL3694287 | 0.68 | DRD2 (0.49) | DRD2DRD4 | |
| SCHEMBL16151185 | 0.68 | EGFR (0.54) | FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |