Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.61 |
| ▸ | RARB | P10826 | 8/20 | 0.61 |
| ▸ | RXRB | P28702 | 7/20 | 0.61 |
| ▸ | RARG | P13631 | 6/20 | 0.61 |
| ▸ | RXRG | P48443 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.60 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.57 |
| ▸ | RARA | P10276 | 5/20 | 0.57 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422927 | 0.90 | RXRA (0.70) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL2788640 | 0.90 | CYP3A4 (0.70) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL7896511 | 0.89 | RXRA (0.63) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL6901737 | 0.85 | RXRA (0.61) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL7761329 | 0.84 | RARB (0.80) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL8733241 | 0.83 | RARB (0.83) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL9047780 | 0.83 | RARB (0.51) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL10459708 | 0.82 | RXRA (0.56) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL2194599 | 0.82 | RARB (0.82) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL9319204 | 0.81 | CYP3A4 (0.67) | RXRARARBRXRBRARGRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |
| EP-1048659-A1 | RETINOID RECEPTOR AGONISTS | Institute of Medicinal Molecular Design, Inc. (JP) | 2000-11-02 | — | — | EP | disclosed |