Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 10/20 | 0.51 |
| ▸ | RARG | P13631 | 9/20 | 0.51 |
| ▸ | RARA | P10276 | 9/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.51 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | RXRA | P19793 | 5/20 | 0.48 |
| ▸ | RXRB | P28702 | 4/20 | 0.48 |
| ▸ | RXRG | P48443 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | HNF4A | P41235 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9051406 | 0.87 | RARB (0.68) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL31191789 | 0.87 | RARB (0.68) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL7899482 | 0.83 | RXRA (0.61) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL10459708 | 0.82 | RXRA (0.56) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL2788640 | 0.81 | CYP3A4 (0.70) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9050990 | 0.81 | RARB (0.47) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL8158825 | 0.79 | PDE4B (0.56) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL7422927 | 0.79 | RXRA (0.70) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL8165528 | 0.78 | PDE4B (0.43) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL6901737 | 0.77 | RXRA (0.61) | RARBRARGRARACYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995033745-A9 | NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY | — | 1996-01-18 | — | — | WO | disclosed |
| WO-1995033745-A2 | NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY | SRI INTERNATIONAL (US) | 1995-12-14 | — | — | WO | disclosed |