Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 14/20 | 0.43 |
| ▸ | RARG | P13631 | 14/20 | 0.43 |
| ▸ | RARA | P10276 | 12/20 | 0.43 |
| ▸ | RXRA | P19793 | 6/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900994 | 1.00 | RARB (0.43) | RARBRARGRARARXRARXRB | |
| SCHEMBL7759633 | 0.82 | CYP26A1 (0.56) | RARBRARGRARARXRARXRB | |
| SCHEMBL7760216 | 0.79 | BACE1 (0.45) | RARBRARGRARARXRARXRB | |
| SCHEMBL7024905 | 0.73 | RXRA (0.51) | RARBRARGRARARXRARXRB | |
| SCHEMBL7024909 | 0.73 | RXRA (0.51) | RARBRARGRARARXRARXRB | |
| SCHEMBL7756578 | 0.70 | RXRA (0.58) | RARBRARGRARARXRARXRB | |
| SCHEMBL7756582 | 0.70 | RXRA (0.58) | RARBRARGRARARXRARXRB | |
| SCHEMBL7889498 | 0.69 | RXRA (0.52) | RARBRARGRARARXRARXRB | |
| SCHEMBL7756631 | 0.69 | RXRA (0.52) | RARBRARGRARARXRARXRB | |
| SCHEMBL7761301 | 0.68 | RXRA (0.49) | RARBRARGRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |