SCHEMBL7901522

SCHEMBL7901522

COc1cc(O)c(C(=O)CCl)c(OC)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.65
USP2 O75604 2/20 0.65
MAPK1 P28482 2/20 0.65
SMN1; SMN2 Q16637 1/20 0.65
CYP2D6 P10635 1/20 0.62
CYP2C19 P33261 1/20 0.62
ABCG2 Q9UNQ0 6/20 0.52
NFKB1 P19838 2/20 0.50
NFKB2 Q00653 2/20 0.50
RELA Q04206 2/20 0.50
DPP4 P27487 1/20 0.50
MAPT P10636 3/20 0.49
KMT2A Q03164 3/20 0.49
TP53 P04637 2/20 0.49
ATM Q13315 1/20 0.49
HSD17B10 Q99714 1/20 0.49
KDM4E B2RXH2 2/20 0.48
MEN1 O00255 2/20 0.48
HPGD P15428 2/20 0.48
TDP1 Q9NUW8 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL827858 0.90 CYP3A4 (0.53) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6
SCHEMBL9119401 0.88 SYNJ2 (0.54) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6
SCHEMBL21275479 0.85 CYP3A4 (0.67) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6
SCHEMBL30002388 0.85 CYP3A4 (0.67) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6
SCHEMBL30506419 0.85 CYP3A4 (0.67) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6
SCHEMBL2874467 0.85 CYP3A4 (0.67) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6
SCHEMBL11105157 0.83 CYP3A4 (0.65) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6
SCHEMBL12301477 0.83 CYP3A4 (0.65) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6
SCHEMBL7905410 0.82 CYP3A4 (0.47) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6
SCHEMBL7228401 0.82 CYP3A4 (0.46) CYP3A4USP2MAPK1SMN1; SMN2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015027833-A1 CYCLOPENTADIONE OXIME ESTER AND APPLICATION THEREOF 北京英力科技发展有限公司 (CN) 2015-03-05 WO disclosed
WO-2015027702-A1 CYCLOPENTANEDIONE OXIME ESTER AND APPLICATION THEREOF 北京英力科技发展有限公司 (CN) 2015-03-05 WO disclosed
US-RE37094-E1 Heterocyclic substituted acylaminothiazoles, their preparation and pharmaceutical compositions containing them SANOFI (FR) 2001-03-13 US disclosed
US-5189049-A Cholecystokinin and gastrin inhibitors SANOFI (FR) 1993-02-23 US disclosed