Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 6/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900021 | 0.89 | PROKR1 (0.34) | PADI4PROKR1KLK5SCN9AHRH2 | |
| SCHEMBL2791987 | 0.86 | PROKR1 (0.35) | PROKR1P2RX3ITGB3ITGA2B | |
| SCHEMBL7891183 | 0.85 | PADI4 (0.40) | PADI4PROKR1KLK5ACESCN9A | |
| SCHEMBL2790219 | 0.83 | PADI4 (0.41) | PADI4PROKR1KLK5ACECNR2 | |
| SCHEMBL7900016 | 0.82 | PROKR1 (0.42) | PADI4PROKR1SCN9ACNR2 | |
| SCHEMBL7897738 | 0.82 | PADI4 (0.37) | PADI4PROKR1KLK5ACESCN9A | |
| SCHEMBL7898758 | 0.81 | CNR2 (0.36) | PADI4KLK5ACESCN9ACNR2 | |
| SCHEMBL7891178 | 0.81 | CNR2 (0.36) | PADI4KLK5ACESCN9ACNR2 | |
| SCHEMBL7897490 | 0.81 | PADI4 (0.41) | PADI4PROKR1KLK5CNR2HRH2 | |
| SCHEMBL7900939 | 0.80 | TP53 (0.37) | PADI4PROKR1KLK5ACESCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |