Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2790320 | 0.90 | KDM4E (0.42) | TP53KDM4EPROKR1POLBMAPT | |
| SCHEMBL7891183 | 0.89 | PADI4 (0.40) | PROKR1KLK5ACECACNA1BPADI4 | |
| SCHEMBL7893386 | 0.89 | PROKR1 (0.38) | PROKR1KLK5ACECACNA1BPADI4 | |
| SCHEMBL762687 | 0.82 | HRH1 (0.41) | TP53POLBCTSSCTSKCYP3A4 | |
| SCHEMBL2790219 | 0.80 | PADI4 (0.41) | PROKR1KLK5ACEPADI4CNR2 | |
| SCHEMBL7901541 | 0.80 | PADI4 (0.36) | PROKR1KLK5ACEPADI4CNR2 | |
| SCHEMBL2817635 | 0.80 | PROKR1 (0.39) | TP53PROKR1POLBMAPTSMN1; SMN2 | |
| SCHEMBL2791612 | 0.80 | PROKR1 (0.39) | TP53PROKR1POLBMAPTSMN1; SMN2 | |
| SCHEMBL2790508 | 0.79 | FPR2 (0.34) | TP53KDM4ESMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL763469 | 0.79 | HRH1 (0.45) | TP53KLK5POLBCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |