Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 12/20 | 0.62 |
| ▸ | MMP13 | P45452 | 12/20 | 0.62 |
| ▸ | MMP1 | P03956 | 11/20 | 0.62 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 5/20 | 0.43 |
| ▸ | MMP3 | P08254 | 5/20 | 0.43 |
| ▸ | MMP8 | P22894 | 4/20 | 0.43 |
| ▸ | MMP12 | P39900 | 4/20 | 0.43 |
| ▸ | MMP14 | P50281 | 4/20 | 0.43 |
| ▸ | MMP16 | P51512 | 4/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930650 | 0.81 | MMP13 (0.81) | MMP9MMP13MMP1PPARGNFE2L2 | |
| SCHEMBL6930645 | 0.81 | MMP13 (0.81) | MMP9MMP13MMP1PPARGNFE2L2 | |
| SCHEMBL6934283 | 0.76 | MMP13 (1.00) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL6934281 | 0.76 | MMP13 (1.00) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7516820 | 0.76 | MMP13 (0.54) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7555235 | 0.76 | MMP13 (0.56) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7378971 | 0.75 | MMP13 (0.49) | MMP9MMP13MMP1NFE2L2MMP2 | |
| SCHEMBL6931515 | 0.75 | MMP9 (0.73) | MMP9MMP13MMP1PPARGNFE2L2 | |
| SCHEMBL6931521 | 0.75 | MMP9 (0.73) | MMP9MMP13MMP1PPARGNFE2L2 | |
| SCHEMBL7508946 | 0.74 | ALDH1A1 (0.45) | MMP9MMP13MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197770-B1 | ENZYME INHIBITORS; ANTIARTHRITIC AGENTS; BONE DISORDERS | THE PROCTER & GAMBLE CO. | 2001-03-06 | — | — | US | claimed |
| US-6197770-B1 | ENZYME INHIBITORS; ANTIARTHRITIC AGENTS; BONE DISORDERS | THE PROCTER & GAMBLE CO. | 2001-03-06 | — | — | US | disclosed |