Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2788887 | 0.93 | PROKR1 (0.39) | PROKR1SCN9ACNR2HTR4CYP3A4 | |
| SCHEMBL7897503 | 0.91 | SCN9A (0.32) | KLK5SCN9AHRH2HRH1GPR119 | |
| SCHEMBL7891211 | 0.89 | PROKR1 (0.42) | PROKR1KLK5SCN9ACNR2HRH2 | |
| SCHEMBL7899697 | 0.89 | PROKR1 (0.39) | PROKR1KLK5SCN9ACNR2HRH2 | |
| SCHEMBL7902566 | 0.87 | PROKR1 (0.38) | PROKR1KLK5SCN9ACNR2HRH2 | |
| SCHEMBL2789639 | 0.87 | PROKR1 (0.42) | PROKR1SCN9ACNR2HTR4CYP3A4 | |
| SCHEMBL2814433 | 0.86 | PROKR1 (0.39) | PROKR1KLK5SCN9ACNR2HRH2 | |
| SCHEMBL2814434 | 0.86 | PROKR1 (0.39) | PROKR1KLK5SCN9ACNR2HRH2 | |
| SCHEMBL7897770 | 0.86 | PROKR1 (0.37) | PROKR1KLK5SCN9ACNR2HRH2 | |
| SCHEMBL2788344 | 0.86 | PROKR1 (0.38) | PROKR1KLK5SCN9ACNR2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |