Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791931 | 0.93 | SCN9A (0.33) | SCN9ARENCYP3A4ALDH1A1TSHR | |
| SCHEMBL7901828 | 0.91 | PROKR1 (0.37) | SCN9AGPR119KLK5HRH2HRH1 | |
| SCHEMBL7898811 | 0.90 | ALOX5AP (0.30) | ALOX5APFEN1KLK5RENCYP3A4 | |
| SCHEMBL7900800 | 0.90 | ALOX5AP (0.30) | ALOX5APFEN1KLK5RENCYP3A4 | |
| SCHEMBL7905913 | 0.89 | CACNA1B (0.35) | SCN9AKLK5EEF2KHRH2HRH1 | |
| SCHEMBL7890024 | 0.89 | KLK5 (0.36) | SCN9AALOX5APFEN1KLK5HRH2 | |
| SCHEMBL2813838 | 0.89 | KLK5 (0.36) | SCN9AALOX5APFEN1KLK5HRH2 | |
| SCHEMBL2813840 | 0.89 | KLK5 (0.36) | SCN9AALOX5APFEN1KLK5HRH2 | |
| SCHEMBL7901258 | 0.87 | PABPC1 (0.33) | KLK5HRH2HRH1ATM | |
| SCHEMBL7898847 | 0.87 | MMP13 (0.35) | KLK5ATMCYP3A4TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |