Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7896651 | 0.87 | PRMT5 (0.44) | MEN1ALDH1A1MAPTKMT2APRMT5 | |
| SCHEMBL7900007 | 0.82 | USP30 (0.44) | PRMT5WDR77KDM1AJAK2JAK1 | |
| SCHEMBL5213286 | 0.71 | HDAC11 (0.47) | MEN1KMT2ACHRM2CHRM4CHRM1 | |
| SCHEMBL5880343 | 0.71 | HDAC11 (0.47) | MEN1KMT2ACHRM2CHRM4CHRM1 | |
| SCHEMBL7897488 | 0.71 | USP30 (0.42) | MEN1ALDH1A1MAPTKMT2AKDM1A | |
| SCHEMBL7893412 | 0.71 | ALOX5AP (0.39) | PRMT5WDR77KDM1AJAK2JAK1 | |
| SCHEMBL5849071 | 0.71 | MAPK1 (0.52) | PRMT5WDR77GPR119CHRM2CHRM4 | |
| SCHEMBL7901892 | 0.70 | MAPK1 (0.49) | MEN1ALDH1A1MAPTKMT2APRMT5 | |
| SCHEMBL31364851 | 0.70 | MEN1 (0.53) | MEN1ALDH1A1MAPTKMT2AGPR119 | |
| SCHEMBL23697540 | 0.70 | PRMT5 (0.51) | PRMT5WDR77KDM1AUSP30HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |