Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898726 | 0.86 | USP30 (0.46) | GPR119USP30MEN1ALDH1A1MAPT | |
| SCHEMBL7900422 | 0.83 | BTK (0.44) | GPR119JAK2JAK1PRMT5WDR77 | |
| SCHEMBL7898292 | 0.83 | BTK (0.42) | GPR119JAK2JAK1USP30HPGDS | |
| SCHEMBL626068 | 0.79 | USP30 (0.45) | MAPK1GPR119JAK2JAK1PRMT5 | |
| SCHEMBL627261 | 0.79 | USP30 (0.45) | MAPK1GPR119JAK2JAK1PRMT5 | |
| SCHEMBL626070 | 0.79 | USP30 (0.45) | MAPK1GPR119JAK2JAK1PRMT5 | |
| SCHEMBL626069 | 0.79 | USP30 (0.45) | MAPK1GPR119JAK2JAK1PRMT5 | |
| SCHEMBL627260 | 0.79 | USP30 (0.45) | MAPK1GPR119JAK2JAK1PRMT5 | |
| SCHEMBL7901250 | 0.78 | HTR6 (0.45) | GPR119JAK2JAK1USP30HPGDS | |
| SCHEMBL7906017 | 0.77 | HPGDS (0.42) | GPR119JAK2JAK1HPGDSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |